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Minimal (one)quinupristin/dalfopristin will improve the stage or effect of paclitaxel protein bound by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Minor/Importance Unfamiliar.quinupristin/dalfopristin will increase the degree or impact of vardenafil by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.